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KMID : 0374919960170010079
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Inje Medical Journal
1996 Volume.17 No. 1 p.79 ~ p.84
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A Comparativd Study of Prophylactic Effect of Intravesical Instillation of Adriamycin, Mitomycin C and BCG at Superficial Bladder Tumor
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Abstract
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We tried to compare the prophylactic effect of intravesical administration of Adriamycin(ADR), Mitomycin-C(MMC), and BCG at superficial bladder tumor. Sixty two patients with biopsy-confirmed transitional cell carcinoma of the bladder were
studied
in a
cooperative protocol comparing intravesical Adriamycin, Mitomycin C and BCG.
Patients have been followed for 6-72months(median 26.4months) at 3-month intervals with cystoscopy, urine cytology and bladder biopsy if recurrence was suspected.
Five of eighteen(27.88%) who received BCG immunotherapy, eleven of twenty five(44%) who received Adriamycin chem-otherapy, seven of nineteen(36.7%) who received Mitomycin C developed tumor recurrence. Among three group, median recurrent period
and
progression rate were not significantly differente statistically(P<0.05). Adverse reaction of three groups was only symptomatic cystitis and occurrence rates of BCG, Mitomycin C and Adriamycin were 5/18(27.8%), 6/19(31.6%) and 13/25(52%).
These data suggest that BCG immunotherapy is superior to Adriamycin chemotherapy in prevention of recurrent superificial transitional cell carcinoma of the urinary bladder and less side effect(P<0.05) but no significant difference was found
between
BCG
and Mitomycin C.
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